Vps18 - VPS18 core subunit of CORVET and HOPS complexes

Predicted to enable several functions, including actin binding activity; syntaxin binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including endosome to lysosome transport; negative regulation of intracellular estrogen receptor signaling pathway; and vesicle docking involved in exocytosis. Predicted to act upstream of or within viral entry into host cell. Is active in presynapse. Orthologous to human VPS18 (VPS18 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Apr 2022]