Tgfbr1 - transforming growth factor, beta receptor 1

Enables several functions, including ATP binding activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor activity, type I. Involved in several processes, including embryo implantation; regulation of pri-miRNA transcription by RNA polymerase II; and response to prostaglandin E. Located in apical plasma membrane; basolateral plasma membrane; and caveola. Part of protein-containing complex. Used to study leiomyoma; osteochondrodysplasia; and pulmonary hypertension. Biomarker of kidney disease and myocardial infarction. Human ortholog(s) of this gene implicated in Ferguson-Smith tumor; Loeys-Dietz syndrome 1; Lynch syndrome; and urinary bladder cancer. Orthologous to human TGFBR1 (transforming growth factor beta receptor 1). [provided by Alliance of Genome Resources, Apr 2022]