Hnrnpa1 - heterogeneous nuclear ribonucleoprotein A1

Enables nucleic acid binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to thapsigargin; and cellular response to tunicamycin. Located in cytosol and nucleoplasmic periphery of the nuclear pore complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3; and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1 like 2). [provided by Alliance of Genome Resources, Apr 2022]