Shh - sonic hedgehog signaling molecule

Predicted to enable several functions, including laminin-1 binding activity; metal ion binding activity; and patched binding activity. Involved in several processes, including animal organ development; negative regulation of cell death; and nervous system development. Acts upstream of or within ventral spinal cord interneuron specification. Located in several cellular components, including membrane raft; neuronal cell body; and synaptic vesicle. Used to study Parkinsonism and myocardial infarction. Biomarker of several diseases, including VACTERL association; chronic kidney disease; esophageal atresia/tracheoesophageal fistula; ocular hypertension; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly. Orthologous to human SHH (sonic hedgehog signaling molecule). [provided by Alliance of Genome Resources, Apr 2022]