Mecom - MDS1 and EVI1 complex locus

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone methyltransferase activity (H3-K9 specific); and protein homodimerization activity. Predicted to be involved in several processes, including hematopoietic stem cell proliferation; negative regulation of JNK cascade; and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including animal organ development; embryonic limb morphogenesis; and positive regulation of brown fat cell differentiation. Predicted to be located in nuclear speck. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myeloid neoplasm. Orthologous to human MECOM (MDS1 and EVI1 complex locus). [provided by Alliance of Genome Resources, Apr 2022]