Notch2 - notch receptor 2

Predicted to enable NF-kappaB binding activity and enzyme binding activity. Involved in cell fate determination; tissue regeneration; and wound healing. Predicted to be located in several cellular components, including cell surface; cilium; and nucleoplasm. Predicted to be integral component of plasma membrane. Predicted to be part of receptor complex. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (notch receptor 2). [provided by Alliance of Genome Resources, Apr 2022]