Nipbl - NIPBL, cohesin loading factor

Predicted to enable several functions, including chromo shadow domain binding activity; histone deacetylase binding activity; and mediator complex binding activity. Predicted to be involved in several processes, including animal organ development; cellular response to X-ray; and sister chromatid cohesion. Predicted to act upstream of or within several processes, including embryonic viscerocranium morphogenesis; fat cell differentiation; and positive regulation of ossification. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of Scc2-Scc4 cohesin loading complex and integrator complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 1. Orthologous to human NIPBL (NIPBL cohesin loading factor). [provided by Alliance of Genome Resources, Apr 2022]