Epas1 - endothelial PAS domain protein 1

Enables DNA-binding transcription factor activity and cobalt ion binding activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including norepinephrine biosynthetic process; positive regulation of lung alveolus development; and regulation of cellular biosynthetic process. Located in cytoplasm and nucleus. Used to study acute kidney failure and intermittent claudication. Biomarker of artery disease (multiple); glucose metabolism disease (multiple); polycystic kidney disease; and renal cell carcinoma. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Orthologous to human EPAS1 (endothelial PAS domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]