Adra1a - adrenoceptor alpha 1A

Enables alpha1-adrenergic receptor activity. Involved in several processes, including activation of phospholipase C activity; positive regulation of cell communication; and regulation of blood circulation. Acts upstream of or within negative regulation of Rho protein signal transduction. Located in T-tubule and Z disc. Is active in GABA-ergic synapse; dopaminergic synapse; and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study bladder neck obstruction. Biomarker of hypertension and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease and hypertension. Orthologous to human ADRA1A (adrenoceptor alpha 1A). [provided by Alliance of Genome Resources, Apr 2022]