Cxcr2 - C-X-C motif chemokine receptor 2

Predicted to enable chemokine binding activity and chemokine receptor activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of neutrophil chemotaxis; and regulation of apoptotic process. Predicted to be located in several cellular components, including cell surface; mast cell granule; and mitotic spindle. Predicted to be active in external side of plasma membrane. Used to study colitis; demyelinating disease; and nephritis. Biomarker of periapical periodontitis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; acute pyelonephritis; end stage renal disease; and urinary bladder cancer. Orthologous to human CXCR2 (C-X-C motif chemokine receptor 2). [provided by Alliance of Genome Resources, Apr 2022]