Irs2 - insulin receptor substrate 2

Enables several functions, including 14-3-3 protein binding activity; insulin receptor binding activity; and phosphatidylinositol 3-kinase binding activity. Involved in cellular response to glucose stimulus and insulin receptor signaling pathway. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and plasma membrane. Biomarker of non-alcoholic fatty liver disease and osteoporosis. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2). [provided by Alliance of Genome Resources, Apr 2022]