Lrp5 - LDL receptor related protein 5

Predicted to enable Wnt-activated receptor activity; Wnt-protein binding activity; and coreceptor activity involved in Wnt signaling pathway. Involved in response to peptide hormone; response to radiation; and retina vasculature morphogenesis in camera-type eye. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Used to study autosomal dominant polycystic kidney disease and polycystic liver disease. Biomarker of osteonecrosis; osteoporosis; and tendinitis. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease. Orthologous to human LRP5 (LDL receptor related protein 5). [provided by Alliance of Genome Resources, Apr 2022]