Enables enzyme binding activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; negative regulation of reactive oxygen species metabolic process; and positive regulation of insulin secretion. Located in mitochondrion. Used to study non-alcoholic fatty liver disease. Biomarker of congestive heart failure; myocardial infarction; obesity; and prediabetes syndrome. Orthologous to human SIRT3 (sirtuin 3). [provided by Alliance of Genome Resources, Apr 2022]