Bag3 - BAG cochaperone 3

Predicted to enable adenyl-nucleotide exchange factor activity and chaperone binding activity. Involved in several processes, including central nervous system development; chaperone-mediated autophagy; and negative regulation of protein targeting to mitochondrion. Located in neuron projection and stress fiber. Used to study glioblastoma. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1HH and myofibrillar myopathy 6. Orthologous to human BAG3 (BAG cochaperone 3). [provided by Alliance of Genome Resources, Apr 2022]