Itgb3 - integrin subunit beta 3

Contributes to fibrinogen binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of cell population proliferation; and positive regulation of signal transduction. Located in apical plasma membrane and cell surface. Part of integrin complex. Colocalizes with focal adhesion. Biomarker of bacterial pneumonia; glomerulonephritis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (integrin subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]