Perp - p53 apoptosis effector related to PMP22

Predicted to be involved in activation of cysteine-type endopeptidase activity and cell-cell adhesion. Predicted to act upstream of or within several processes, including amelogenesis; desmosome organization; and intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to be located in Golgi apparatus and mitochondrion. Predicted to be integral component of plasma membrane. Predicted to be active in cell-cell junction. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Orthologous to human PERP (p53 apoptosis effector related to PMP22). [provided by Alliance of Genome Resources, Apr 2022]