Irf3 - interferon regulatory factor 3

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; promoter-specific chromatin binding activity; and protein homodimerization activity. Involved in cellular response to exogenous dsRNA; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of cytokine production. Predicted to be located in cytosol and mitochondrion. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human IRF3 (interferon regulatory factor 3). [provided by Alliance of Genome Resources, Apr 2022]