Erf - Ets2 repressor factor

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chorio-allantoic fusion; ectodermal cell differentiation; and trophoblast giant cell differentiation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in craniosynostosis. Orthologous to human ERF (ETS2 repressor factor). [provided by Alliance of Genome Resources, Apr 2022]