Tubb4a - tubulin, beta 4A class IVa

Predicted to enable GTP binding activity and calcium ion binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization; mitotic cell cycle; and negative regulation of microtubule polymerization. Predicted to be located in several cellular components, including axoneme; internode region of axon; and neuronal cell body. Predicted to be active in cytoplasm and microtubule. Used to study demyelinating disease. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 6 and torsion dystonia 4. Orthologous to human TUBB4A (tubulin beta 4A class IVa). [provided by Alliance of Genome Resources, Apr 2022]