Irf8 - interferon regulatory factor 8

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cellular response to interferon-gamma; mononuclear cell differentiation; and regulation of gene expression. Predicted to act upstream of or within several processes, including defense response to protozoan; regulation of gene expression; and response to bacterium. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 32A and immunodeficiency 32B. Orthologous to human IRF8 (interferon regulatory factor 8). [provided by Alliance of Genome Resources, Apr 2022]