Wwox - WW domain-containing oxidoreductase

Predicted to enable enzyme binding activity and identical protein binding activity. Predicted to contribute to transcription coactivator activity. Predicted to be involved in cellular response to transforming growth factor beta stimulus; positive regulation of transcription by RNA polymerase II; and regulation of signal transduction. Predicted to act upstream of or within several processes, including apoptotic signaling pathway; osteoblast differentiation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in several cellular components, including Golgi apparatus; mitochondrion; and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to colocalize with microvillus and plasma membrane. Used to study epilepsy. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase). [provided by Alliance of Genome Resources, Apr 2022]