Ercc3 - ERCC excision repair 3, TFIIH core complex helicase subunit

Predicted to enable several functions, including ATP hydrolysis activity; promoter-specific chromatin binding activity; and protein C-terminus binding activity. Involved in embryonic organ development and response to hypoxia. Located in nucleus. Part of transcription factor TFIIH core complex. Biomarker of asphyxia neonatorum. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; photosensitive trichothiodystrophy 2; trichothiodystrophy; xeroderma pigmentosum; and xeroderma pigmentosum group B. Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Apr 2022]