Enables identical protein binding activity. A structural constituent of tooth enamel. Involved in response to calcium ion; response to nutrient; and response to xenobiotic stimulus. Located in Golgi apparatus; endocytic vesicle; and extracellular matrix. Biomarker of autosomal dominant hypocalcemia. Human ortholog(s) of this gene implicated in amelogenesis imperfecta and amelogenesis imperfecta type 1E. Orthologous to several human genes including AMELX (amelogenin X-linked). [provided by Alliance of Genome Resources, Apr 2022]