Atp8b1 - ATPase phospholipid transporting 8B1

Enables phosphatidylserine flippase activity. Predicted to be involved in several processes, including apical protein localization; lipid transport; and nervous system development. Predicted to act upstream of or within bile acid metabolic process. Located in brush border membrane. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Orthologous to human ATP8B1 (ATPase phospholipid transporting 8B1). [provided by Alliance of Genome Resources, Apr 2022]