Capn3 - calpain 3

Enables several functions, including calcium-dependent cysteine-type endopeptidase activity; enzyme binding activity; and titin binding activity. Involved in several processes, including response to calcium ion; response to muscle activity; and sodium-dependent self proteolysis. Located in T-tubule; Z disc; and nucleus. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; and muscular dystrophy. Orthologous to human CAPN3 (calpain 3). [provided by Alliance of Genome Resources, Apr 2022]