Capn1 - calpain 1

Enables several functions, including calcium ion binding activity; calcium-dependent cysteine-type endopeptidase activity; and cytoskeletal protein binding activity. Involved in several processes, including negative regulation of NIK/NF-kappaB signaling; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of leukocyte tethering or rolling. Located in cytosol; membrane; and mitochondrion. Biomarker of acute kidney failure; aortic atherosclerosis; epilepsy; and sciatic neuropathy. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Orthologous to human CAPN1 (calpain 1). [provided by Alliance of Genome Resources, Apr 2022]