Grn - granulin precursor

Predicted to enable chaperone binding activity. Involved in several processes, including chondrocyte proliferation; positive regulation of dendritic spine development; and response to estradiol. Predicted to be located in several cellular components, including late endosome; lysosomal membrane; and trans-Golgi network. Predicted to be active in extracellular region. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor). [provided by Alliance of Genome Resources, Apr 2022]