Axin2 - axin 2

Enables beta-catenin binding activity and protein kinase binding activity. Involved in several processes, including negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; negative regulation of cell population proliferation; and positive regulation of protein kinase activity. Part of protein-containing complex. Human ortholog(s) of this gene implicated in colorectal cancer and endometrial adenocarcinoma. Orthologous to human AXIN2 (axin 2). [provided by Alliance of Genome Resources, Apr 2022]