Gmds - GDP-mannose 4, 6-dehydratase

Predicted to enable GDP-mannose 4,6-dehydratase activity; NADP+ binding activity; and identical protein binding activity. Predicted to be involved in 'de novo' GDP-L-fucose biosynthetic process; GDP-mannose metabolic process; and Notch signaling pathway. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in open-angle glaucoma. Orthologous to human GMDS (GDP-mannose 4,6-dehydratase). [provided by Alliance of Genome Resources, Apr 2022]