Mtrr - 5-methyltetrahydrofolate-homocysteine methyltransferase reductase

Predicted to enable NADPH-hemoprotein reductase activity; [methionine synthase] reductase activity; and nucleotide binding activity. Predicted to be involved in several processes, including S-adenosylmethionine cycle; carboxylic acid metabolic process; and negative regulation of cystathionine beta-synthase activity. Predicted to be located in intermediate filament cytoskeleton and nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); heart disease (multiple); hematologic cancer (multiple); homocystinuria; and homocystinuria-megaloblastic anemia cblE type. Orthologous to human MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase). [provided by Alliance of Genome Resources, Apr 2022]