Col4a1 - collagen type IV alpha 1 chain

Predicted to enable platelet-derived growth factor binding activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in epithelial cell differentiation. Predicted to be located in extracellular region. Predicted to be part of collagen type IV trimer. Predicted to be active in basement membrane and extracellular space. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in brain small vessel disease 1; myocardial infarction; and retinal arterial tortuosity. Orthologous to human COL4A1 (collagen type IV alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]