Itm2b - integral membrane protein 2B

Predicted to enable ATP binding activity and amyloid-beta binding activity. Predicted to be involved in negative regulation of amyloid precursor protein biosynthetic process. Predicted to act upstream of or within extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in Golgi-associated vesicle membrane and extracellular space. Predicted to be integral component of organelle membrane. Predicted to be active in Golgi apparatus and plasma membrane. Human ortholog(s) of this gene implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Orthologous to human ITM2B (integral membrane protein 2B). [provided by Alliance of Genome Resources, Apr 2022]