Eprs1 - glutamyl-prolyl-tRNA synthetase 1

Predicted to enable several functions, including RNA stem-loop binding activity; proline-tRNA ligase activity; and protein homodimerization activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; prolyl-tRNA aminoacylation; and regulation of long-chain fatty acid import into cell. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in cytosol and plasma membrane. Predicted to be part of GAIT complex; aminoacyl-tRNA synthetase multienzyme complex; and ribonucleoprotein complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human EPRS1 (glutamyl-prolyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]