Tlr5 - toll-like receptor 5

Predicted to enable interleukin-1 receptor binding activity and signaling receptor activity. Involved in cellular response to lipopolysaccharide; male gonad development; and positive regulation of nitric oxide biosynthetic process. Located in membrane. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5). [provided by Alliance of Genome Resources, Apr 2022]