Edem3 - ER degradation enhancing alpha-mannosidase like protein 3

Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in mannose trimming involved in glycoprotein ERAD pathway. Predicted to act upstream of or within glycoprotein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum lumen. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human EDEM3 (ER degradation enhancing alpha-mannosidase like protein 3). [provided by Alliance of Genome Resources, Apr 2022]