Predicted to enable axon guidance receptor activity and transmembrane-ephrin receptor activity. Predicted to be involved in several processes, including ephrin receptor signaling pathway; neuron projection development; and tube morphogenesis. Predicted to act upstream of or within central nervous system projection neuron axonogenesis and retinal ganglion cell axon guidance. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Biomarker of malaria. Orthologous to human EPHB3 (EPH receptor B3). [provided by Alliance of Genome Resources, Apr 2022]