Pkp2 - plakophilin 2

Predicted to enable several functions, including alpha-catenin binding activity; intermediate filament binding activity; and protein kinase C binding activity. Involved in several processes, including cell-cell junction organization; lipid homeostasis; and regulation of bicellular tight junction assembly. Located in adherens junction and intercalated disc. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and arrhythmogenic right ventricular dysplasia 9. Orthologous to human PKP2 (plakophilin 2). [provided by Alliance of Genome Resources, Apr 2022]