Spop - speckle type BTB/POZ protein

Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of proteolysis. Predicted to act upstream of or within several processes, including glucose homeostasis; positive regulation of apoptotic process; and regulation of transcription, DNA-templated. Predicted to be located in nuclear speck. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SPOP (speckle type BTB/POZ protein). [provided by Alliance of Genome Resources, Apr 2022]