Predicted to enable 2-(3-amino-3-carboxypropyl)histidine synthase activity. Predicted to be involved in peptidyl-diphthamide biosynthetic process from peptidyl-histidine. Predicted to act upstream of or within cell population proliferation. Predicted to be located in cell junction and nucleoplasm. Orthologous to human DPH1 (diphthamide biosynthesis 1). [provided by Alliance of Genome Resources, Apr 2022]