Alox12b - arachidonate 12-lipoxygenase, 12R type

Predicted to enable arachidonate 12(S)-lipoxygenase activity; arachidonate 8(R)-lipoxygenase activity; and linoleate 9S-lipoxygenase activity. Involved in arachidonic acid metabolic process and hepoxilin biosynthetic process. Predicted to be located in cytosol. Predicted to be active in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 2. Orthologous to human ALOX12B (arachidonate 12-lipoxygenase, 12R type). [provided by Alliance of Genome Resources, Apr 2022]