Skp1 - S-phase kinase-associated protein 1

Predicted to enable several functions, including F-box domain binding activity; beta-catenin binding activity; and cullin family protein binding activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin protein ligase activity; and protein ubiquitination. Predicted to act upstream of or within protein K48-linked ubiquitination and protein monoubiquitination. Predicted to be located in centrosome and cytosol. Predicted to be part of Cul7-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]