Rffl - ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

Predicted to enable enzyme binding activity; p53 binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; and negative regulation of signal transduction. Predicted to act upstream of or within intracellular protein transport. Predicted to be located in endosome membrane. Predicted to be active in cytoplasm and plasma membrane. Biomarker of hypertension. Orthologous to human RFFL (ring finger and FYVE like domain containing E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Apr 2022]