Fzd6 - frizzled class receptor 6

Predicted to enable Wnt-activated receptor activity; Wnt-protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in Wnt signaling pathway; negative regulation of DNA-binding transcription factor activity; and negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including cell proliferation in midbrain; embryonic morphogenesis; and establishment of body hair planar orientation. Predicted to be located in apical plasma membrane; apicolateral plasma membrane; and endoplasmic reticulum membrane. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 1. Orthologous to human FZD6 (frizzled class receptor 6). [provided by Alliance of Genome Resources, Apr 2022]