Nsun2 - NOL1/NOP2/Sun domain family member 2

Enables mRNA (cytidine-5-)-methyltransferase activity and tRNA (cytosine-5-)-methyltransferase activity. Involved in several processes, including RNA methylation; meiotic cell cycle checkpoint signaling; and tRNA stabilization. Acts upstream of or within in utero embryonic development. Located in chromatoid body. Is expressed in several structures, including branchial arch; cardiovascular system; central nervous system; extraembryonic component; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]