Magel2 - MAGE family member L2

Predicted to enable ubiquitin-protein transferase activity. Involved in negative regulation of transcription, DNA-templated and regulation of circadian rhythm. Acts upstream of or within positive regulation of actin nucleation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; egg cylinder; future spinal cord; limb bud; and reproductive system. Used to study Prader-Willi syndrome. Human ortholog(s) of this gene implicated in Schaaf-Yang syndrome. Orthologous to human MAGEL2 (MAGE family member L2). [provided by Alliance of Genome Resources, Apr 2022]