Gfer - growth factor, augmenter of liver regeneration

Enables flavin-linked sulfhydryl oxidase activity. Involved in several processes, including cellular response to actinomycin D; liver regeneration; and negative regulation of cell death. Located in cytosol; extracellular space; and mitochondrion. Used to study acute kidney failure. Biomarker of acute kidney failure; cryptorchidism; and ureteral obstruction. Human ortholog(s) of this gene implicated in kidney failure and renal fibrosis. Orthologous to human GFER (growth factor, augmenter of liver regeneration). [provided by Alliance of Genome Resources, Apr 2022]