Megf8 - multiple EGF-like-domains 8

Predicted to enable calcium ion binding activity. Involved in several processes, including embryonic organ development; generation of neurons; and negative regulation of smoothened signaling pathway. Acts upstream of or within coronary vasculature development; determination of digestive tract left/right asymmetry; and determination of heart left/right asymmetry. Located in nucleus. Is expressed in several structures, including branchial arch; ganglia; heart; limb bud; and telencephalon. Used to study Carpenter syndrome and visceral heterotaxy. Human ortholog(s) of this gene implicated in Carpenter syndrome. Orthologous to human MEGF8 (multiple EGF like domains 8). [provided by Alliance of Genome Resources, Apr 2022]