Lrig2 - leucine-rich repeats and immunoglobulin-like domains 2

Enables signaling receptor binding activity. Acts upstream of or within several processes, including negative regulation of axon regeneration; negative regulation of membrane protein ectodomain proteolysis; and positive regulation of protein localization to cell surface. Located in several cellular components, including growth cone; intracellular vesicle; and neuronal cell body. Is expressed in several structures, including branchial arch; central nervous system; eye; inner ear; and nasal pit. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to human LRIG2 (leucine rich repeats and immunoglobulin like domains 2). [provided by Alliance of Genome Resources, Apr 2022]