Aifm1 - apoptosis-inducing factor, mitochondrion-associated 1

Enables DNA binding activity; FAD binding activity; and NAD(P)H oxidase H2O2-forming activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; mitochondrion organization; and positive regulation of cell death. Acts upstream of or within neuron apoptotic process and regulation of apoptotic DNA fragmentation. Located in cytosol; mitochondrion; and nucleus. Is expressed in several structures, including early embryo; liver; and retina. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to several human genes including TXNDC12 (thioredoxin domain containing 12). [provided by Alliance of Genome Resources, Apr 2022]