Grm4 - glutamate receptor, metabotropic 4

Predicted to enable adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; calcium-dependent protein binding activity; and calmodulin binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within chemical synaptic transmission and learning. Located in neuron projection and parallel fiber to Purkinje cell synapse. Is integral component of presynaptic active zone membrane. Is active in glutamatergic synapse. Is expressed in central nervous system; dorsal root ganglion; foot; sensory organ; and skeleton. Orthologous to human GRM4 (glutamate metabotropic receptor 4). [provided by Alliance of Genome Resources, Apr 2022]